SLC1A1基因多态性与中国汉族人群强迫症的相关性

doi:10.3969/j.issn.2095-9400.2020.03.014

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1458 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：探讨谷氨酸转运体基因（SLC1A1）与中国汉族人群强迫症（OCD）的关系。方法：采用病例对照研究，以125例患者（OCD组）和125例正常人（对照组）作为研究对象，检测SLC1A1基因的3个位点（rs301430、rs301434、rs301979），分析这些位点等位基因、基因型分布，以及单倍体与OCD之间的关系。结果：3个位点的等位基因和基因型频率分布在OCD组和对照组中的差异无统计学意义（P＞0.05）。经性别分层分析，相较于对照组，女性患者rs301979位点等位基因和基因型频率分布与对照组差异有统计学意义（χ2=7.875，P=0.019；χ2=7.331，P=0.007），而男性患者中所有位点的等位基因和基因型频率分布差异均无统计学意义（P＞0.05）。三位点单倍体T-A-G在2组中的差异有统计学意义（χ2=6.206，P=0.013）。结论：SLC1A1基因rs301979位点可能是女性OCD的易感基因位点，rs301430、rs301434、rs301979的单倍体T-A-G可能与中国汉族人群OCD发病相关。

	服务
	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	任建娟
	唐牟尼
	陈晓莹
	傅正闯

关键词 ：强迫性障碍, 谷氨酸转运体基因, 多态性, 易感基因

Abstract：Objective: To investigate the relationship between solute carrier family 1 member 1 gene (SLC1A1) and obsessive-compulsive disorder (OCD) in Chinese Han population. Methods: A case-control study was conducted on 125 patients (OCD group) and 125 normal people (control group) to detect 3 loci of SLC1A1 gene (rs301430, rs301434, rs301979). The allele and genotype distribution of these loci and the relationship between haploid and OCD were analyzed. Results: There was no significant difference in allele and genotype frequency distribution of 3 loci between OCD group and control group (P>0.05). Gender stratified analysis showed that the frequency distribution of allele and genotype of rs301979 site in female patients was significantly different from that in the control group (χ2=7.875, P=0.019; χ2=7.331, P=0.007), while the distribution of allele and genotype frequency of all loci in male patients was not statistically significant (P>0.05). The difference between haploid T-A-G of 3-loci in the 2 groups was statistically significant (χ2=6.206, P=0.013). Conclusion: The rs301979 site of SLC1A1 gene may be the susceptibility gene site of female OCD, and the haploid T-A-G of rs301430, rs301434 and rs301979 may be related to the incidence of OCD in Chinese Han population.

Key words： obsessive-compulsive disorder solute carrier family 1 member 1 polymorphism susceptibility gene

基金资助:杭州市科技计划项目（20181228Y88）。

通讯作者: 唐牟尼，主任医师，Email：tangmuni@hotmail.com

作者简介: 任建娟（1984-），女，浙江杭州人，主治医师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/10.3969/j.issn.2095-9400.2020.03.014 或 https://xb.wmu.edu.cn/CN/Y2020/V50/I3/237

[1] NAAIJEN J, LYTHGOE D J, AMIRI H, et al. Fronto-striatal glutamatergic compounds in compulsive and impulsive syndromes: a review of magnetic resonance spectroscopy stud-ies[J]. Neurosci Biobehav Rev, 2015, 52: 74-88.
[2] CHAKRABARTY K, BHATTACHARYYA S, CHRISTOPHER R, et al. Glutamatergic dysfunction in OCD[J]. Neuropsychopharmacology, 2005, 30(9): 1735-1740.
[3] CORIC V, TASKIRAN S, PITTENGER C, et al. Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial[J]. Biol Psychiatry, 2005, 58(5): 424-428.
[4] GRANT P, LOUGEE L, HIRSCHTRITT M, et al. An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder[J]. J Child Adolesc Psychopharmacol, 2007, 17(6): 761-767.
[5] BERGLES D E, JAHR C E. Synaptic activation of glutamate transporters in hippocampal astrocytes[J]. Neuron, 1997, 19(6): 1297-1308.
[6] BERGLES D E, JAHR C E. Transporters buffer synaptically released glutamate on a submillisecond time scale[J]. J Neurosci, 1997, 17(12): 4672-4687.
[7] Walitza S, Wendland J R, Gruenblatt E, et al. Genetics of early-onset obsessive-compulsive disorder[J].Eur Child Adolesc Psychiatry, 2010, 19(3): 227-235.
[8] ARNOLD P D, SICARD T, BURROUGHS E, et al. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder[J]. Arch Gen Psychiatry, 2006, 63(7): 769-776.
[9] DICKEL D E, VEENSTRA-VANDERWEELE J, COX N J,
et al. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder[J]. Arch Gen Psychiatry, 2006, 63(7): 778-785.
[10] SHUGART Y Y, WANG Y, SAMUELS J F, et al. A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families[J]. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(6): 886-892.
[11] SAMUELS J, WANG Y, RIDDLE M A, et al. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder[J]. Am J Med Genet B Neuropsychiatr Genet, 2011,156B(4): 472-477.
[12] STEWART S E, FAGERNESS J A, PLATKO J, et al. Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder[J]. Am J Med Genet B Neuropsychiatr Genet, 2007, 144B(8): 1027-1033.
[13] Wu H S, Wang X M, Xiao Z P, et al. Association between SLC1A1 gene and early-onset ocd in the han chinese population: A case-control study[J]. J Mol Neurosci, 2013, 50(2): 353-359.
[14] STEWART S E, MAYERFELD C, ARNOLD P D, et al. Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1[J]. Am J Med Genet B Neuropsychiatr Genet, 2013, 162B(4): 367-379.
[15] Shi Y Y, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci[J]. Cell Res, 2005, 15(2): 97-98.
[16] HETTEMA J M, NEALE M C, KENDLER K S, et al. A review and meta-analysis of the genetic epidemiology of anxiety disorders[J]. Am J Psychiatry, 2001, 158(10): 1568-1578.
[17] VEENSTRA-VANDER WEELE J, KIM S J, GONEN D,
et al. Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder[J]. Mol Psychiatry, 2001, 6(2): 160-167.
[18] HANNA G L, VEENSTRA-VANDER WEELE J, COX N J, et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric pro-bands[J]. Am J Med Genet, 2002, 114(5): 541-552.
[19] KIM H W, KANG J I, HWANG E H, et al. Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean popula-tion[J]. PLoS one, 2018, 13(1): e0190593.
[20] ZHANG K, CAO L, ZHU W, et al. Association between the efficacy of fluoxetine treatment in obsessive-compulsive disorder patients and SLC1A1 in a Han Chinese population[J]. Psychiatry Res, 2015, 229(1-2): 631-632.
[21] 丛金芝, 张心华. SLC1A1基因rs3087879位点多态性与强迫症的关系[J]. 青岛大学医学院学报, 2016, 3(52): 345-347, 351.