急性心肌梗死患者cd42b、cd62p、Hcy及hs-CRP与冠状动脉病变程度的相关性

doi:10.3969/j.issn.2095-9400.2019.12.016

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摘要目的：研究急性心肌梗死（AMI）患者cd42b、cd62p、同型半胱氨酸（Hcy）及超敏C反应蛋白（hs-CRP）与冠状动脉病变程度的相关性。方法：纳入2016年1月至2018年9月于邯郸市第一医院治疗的AMI患者154例，并依据Gensini评分分为L组（≤55分）、M组（56～84分）和H组（85～172分）。比较3组患者cd42b、cd62p、Hcy及hs-CRP的水平差异。比较不同冠状动脉病变支数患者cd42b、cd62p、Hcy及hs-CRP水平的差异。对cd42b、cd62p、Hcy及hs-CRP与冠状动脉病变程度的相关性进行分析。结果：3组间cd62p、Hcy和hs-CRP水平差异均有统计学意义（P＜0.05），其中M组cd62p、Hcy和hs-CRP水平均显著高于L组（P＜0.05），H组cd62p、Hcy和hs-CRP水平均显著高于L组和M组（P＜0.05）。3组间cd42b水平差异无统计学意义。不同病变支数cd62p、Hcy及hs-CRP水平差异有统计学意义（P＜0.05），病变数2支和3支的患者cd62p、Hcy及hs-CRP水平显著高于病变1支的患者（P＜0.05）。病变数3支的患者cd62p、Hcy及hs-CRP水平显著高于2支的患者（P＜0.05）。cd62p、Hcy和hs-CRP与Gensini评分呈显著正相关（P＜0.05）。结论：cd62p、Hcy及hs-CRP与AMI患者冠状动脉病变程度呈显著正相关，可以通过对cd62p、Hcy及hs-CRP水平的检测了解AMI患者冠状动脉病变程度。

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关键词 ：急性心肌梗死, cd42b, cd62p, 同型半胱氨酸, 超敏C反应蛋白, 冠状动脉病变

Abstract：Objective: To investigate the correlation between cd42b, cd62p, homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) and severity of coronary artery disease in patients with acute myocardial infarction (AMI). Methods: Totally 154 patients with AMI were enrolled. According to the Gensini score, they were divided as L group (≤55 points), M group (56-84 points) and H group (85-172 points). The differences in levels of cd42b, cd62p, Hcy and hs-CRP were compared between the three groups. The differences in cd42b, cd62p, Hcy and hs-CRP levels were compared between patients with different coronary lesions. The correlation between cd42b, cd62p, Hcy and hs-CRP and the extent of coronary lesions was analyzed. Results: The levels of cd62p, Hcy and hs-CRP were significantly different between groups (P<0.05). The cd62p, Hcy and hs-CRP levels in group M were significantly higher than those in group L (P<0.05). The levels of cd62p, Hcy, hs-CRP and hs-CRP were significantly higher in group H than those of L and M groups (P<0.05). There was no significant difference in cd42b levels between groups. The levels of cd62p, Hcy and hs-CRP in different lesions were significantly different (P<0.05). The levels of cd62p, Hcy and hs-CRP in patients with 2 and 3 lesions were significantly higher than those with 1 lesion (P<0.05). The levels of cd62p, Hcy and hs-CRP in patients with 3 lesions were significantly higher than those with 2 lesions (P<0.05). With the increase of Gensini score, cd42b showed a downward trend, with group L the highest level of cd42b, and group H the lowest level of cd42b. There was a significant positive correlation between cd62p, Hcy and hs-CRP and Gensini score (P<0.05). Conclusion: cd62p, Hcy and hs-CRP are significantly positively correlated with the degree of coronary artery lesions in patients with AMI, suggesting the detection of cd62p, Hcy and hs-CRP levels could be used to understand the degree of coronary artery lesions in AMI patients.

Key words： acute myocardial infarction cd42b cd62p homocysteine hypersensitive C-reactive protein coronary artery disease

收稿日期: 2019-04-19

基金资助:邯郸市科技计划项目（1623208064-5）。

作者简介: 冯艳（1983-），女，河北邯郸人，主管检验师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/10.3969/j.issn.2095-9400.2019.12.016 或 https://xb.wmu.edu.cn/CN/Y2019/V49/I12/930

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