索拉菲尼对行肝动脉化疗栓塞术治疗的BCLC B/C期肝细胞癌患者的疗效

doi:10.3969/j.issn.2095-9400.2019.08.009

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摘要目的：研究索拉菲尼对接受动脉化疗栓塞术（TACE）治疗的巴塞罗那分期（BCLC）B/C期肝细胞癌患者疗效的增益作用。方法：选取2013年1月至2017年12月在丽水市中心医院行TACE治疗的BCLC B/C期肝细胞癌患者84例，所有患者均经穿刺活检证实为肝细胞癌。根据有无服用索拉菲尼分为TACE组（45例）和索拉菲尼联合TACE组（联合组，39例），所有入组患者定期随访监测3年，并记录临床资料，比较2组患者之间的疾病控制及生存获益情况，明确索拉菲尼对TACE的增益作用。结果：联合组的肿瘤反应（为64.1%）明显优于TACE组（为37.21%）（P=0.008）；TACE组患者的6个月、1年、2年和3年生存率分别为60%、40%、13.3%和8.9%，联合组为82.1%、51.3%、30.8%和16.9%；TACE组和联合组的总生存时间分别为12.9个月和19.3个月，无进展生存时间分别为6.0个月和16.2个月，联合组的总生存时间（P=0.032）和无进展生存时间（P=0.006）均显著优于TACE组。结论：针对行TACE治疗的BCLC B/C期肝细胞癌患者，索拉菲尼能够使患者的整体生存期显著获益，提高肝癌TACE的治疗效果。

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	程适妙
	骆松梅
	李莉
	吕秀玲
	吴徐璐
	翁巧优
	陈敏江
	杨宏远
	纪建松

关键词 ：索拉菲尼, 经动脉化疗栓塞术, 肝细胞癌, 巴塞罗那分期, 生存期

Abstract：Objective: To explore the synergistic effect of the sorafenib on the efficacy of BCLC B/C hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE). Methods: Eighty-four patients with BCLC stage B/C hepatocellular carcinoma who were treated with TACE in our hospital from January 2013 to December 2017 were retrospectively selected. All patients were confirmed as hepatocellular carcinoma by biopsy, and further divided into TACE group (45 patients) and the sorafenib combined with TACE group (combination group, 39 patients) according to the presence or absence of sorafenib. All enrolled patients were followed up for three years, and clinical data were recorded. The disease control and survival benefits between the two groups were compared, and the synergistic effect of sorafenib on TACE was determined. Results: The tumor response of the combination group (64.1%) was significantly better than that of the TACE group (37.21%) (P=0.008). The 6-month, 1-year, 2-year and 3-year survival rates of patients in the TACE group were 60%, 40%, 13.3% and 8.9%, respectively, and those in the combination group were 82.1%, 51.3%, 30.8% and 16.9%. The overall survival time of the TACE group and the combination group was 12.9 months and 19.3 months, respectively; the progression-free survival time was 6.044 months and 16.218 months, respectively. The overall survival time (P=0.032) and progression-free survival time (P=0.006) of the combination group were significantly better than that of TACE group. Conclusion: For BCLC B/C stage HCC patients treated with TACE, sorafenib could significantly benefit the overall survival of patients and improve the TACE efficacy of HCC.

Key words： sorafenib transcatheter arterial chemoembolization hepatocellular carcinoma Barcelona Clinic Liver Cancer stage survival time

基金资助:浙江省分析测试科技计划项目（2018C37039）；浙江省医药卫生科技计划项目（2016KYB335）。

通讯作者: 纪建松，主任医师，Email：jjstcty@sina.com。

作者简介: 程适妙（1988-），女，浙江丽水人，药师，硕士。

链接本文:

https://xb.wmu.edu.cn/CN/10.3969/j.issn.2095-9400.2019.08.009 或 https://xb.wmu.edu.cn/CN/Y2019/V49/I8/594

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