ZHOU Yuping. Clinical value of the combined detection of three indicators for early diagnosis of diabetic nephropathy[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(6): 452-.
Abstract：Objective: To explore the clinical value of the combined detection of retinol binding protein 4 (RBP4), cystatin C (CysC) and homocysteine (Hcy) for early diagnosis of diabetic nephropathy (DN). Methods: 98 diagnosed patients with type 2 diabetes were divided into 3 groups according to the excretion rate of urine albumin: normal albumin group (group A), trace albumin group (group B) and mass albumin group (group C), at the same time, 30 healthy subjects were taken as the nephropathy control group (NC group). The levels of serum RBP4, CysC, Hcy, blood urea nitrogen (BUN) and creatinine (Cr) were detected, and the results were statistically processed. Results: The serum RBP4, CysC and Hcy in group A, B and C were higher than those of NC group, and those of the group B and C were higher than those of group A, with statistically significant differences. There was no statistically significant difference of serum BUN and Cr level between group A, group B and NC group. ROC-AUC of combined detection in group B was 0.952, showing a higher accuracy. AUCs of RBP4, Hcy and CysC were 0.850, 0.824 and 0.817, while AUCs of BUN and Cr were 0.643 and 0.633. Conclusion: The serum RBP4, Hcy and CysC are sensitive indicators for early diagnosis of DN. And the combined detection can improve the accuracy in early diagnosis of DN.
