Enhanced osseointegration of nano textured Ti6Al4V implants by etching
WU Weili1, LUO Jun1, YING Yukang1, ZHU Haiqian1, TAO Dan1, XU Panshu1, YU Weiqiang2
1.Department of Stomatological, the Central Hospital of Taizhou, Taizhou 318000, China; 2.Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai 200011, China
WU Weili,LUO Jun,YING Yukang, et al. Enhanced osseointegration of nano textured Ti6Al4V implants by etching[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2019, 49(4): 285-288.
Abstract：Objective: To evaluate the removal torque and bone gene expression of nano textured Ti6Al4V implants in vivo. Methods: The implants were divided as group of nano textured Ti6Al4V implants by etching and as the control of the machined implants. All the implants were placed in the tibia of rabbits. After four weeks, removal torque was analyzed by a digital torque gauge. New bone was found with fluorescence microscope. The gene expression of Runx2, Col-1 and OCN was examined using real-time PCR. Results: Nano textured Ti6Al4V implants by etching showed significantly bigger removal torque (P<0.05) and higher Runx2, Col-1 and OCN gene expression (P<0.05) than the machined implants. In addition, more new bone was found around nano textured Ti6Al4V implant around. Conclusion: The nano textured Ti6Al4V implants by etching could improve the early osseointegration processin vivo, which may be applied clinically in the future.
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