Preparation of a novel iron-containing polymeric nanobubbles ultrsound contrast agents and its acoustic properties
LI Jiaping1, JIANG Yan1, WANG Doudou1, YU Fangfang2, CHENG Yueyue2, LIU Zhe1
1.School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China; 2.Department of Ultrasonic Imaging, the Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China
LI Jiaping,JIANG Yan,WANG Doudou, et al. Preparation of a novel iron-containing polymeric nanobubbles ultrsound contrast agents and its acoustic properties[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2019, 49(4): 249-252，257.
Abstract：Objective: To prepare iron-containing polybutyl cyanoacrylate (PBCA) hybrid nanobubbles (UPNBs) and to explore the properties and ultrasonic imaging intensity of hybrid nanobubbles under different conditions. Methods: The nanobubbles (NBs) were produced via emulsion polymerization of PBCA and were purified by a simple mechanical agitation, and the UPNBs were prepared via an oil-in-water (O/W) encapsulation of iron oxide nanoparticles in the bubble shell. The mean diameter and concentration of UPNBs were analyzed by using a Beckmann Coulter Counter. The iron concentration in different UPNBs batches was determined by inductively coupled plasma mass spectrometer (ICP-MS). Furthermore, the contrast of UPNBs in ultrasound (US) imaging was evaluated by an ultrasound scanner. Results: These polymeric NBs exhibited strong contrast in US imaging. Moreover, with the iron concentration increasing, the size of UPNBs changed slightly and they had excellent backscattering capability in US imaging. Conclusion: These nanobubbles are candidates as hybrid imaging agents for US molecular imaging, which may be potential vehicles for MRI-guided US-mediated drug and gene delivery.
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