脐血Betatrophin水平与巨大儿发生的关系

doi:10.3969/j.issn.2095-9400.2019.02.008

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摘要目的：探讨脐血血清促代谢因子（Betatrophin）水平与巨大儿的关系。方法：采用横断面研究的方法。选择巨大儿、正常出生体质量儿（NBW）各30例。检测脐血、母血Betatrophin水平，分析脐血血清Betatrophin水平与巨大儿生长发育指标、脂代谢指标和脂联素等的相关性。结果：巨大儿、NBW的脐血血清Betatrophin水平分别为（1 088.338±67.749）、（929.487±80.949）ng/L，差异有统计学意义（t=8.242，P＜0.001）；2组新生儿血脂各指标水平比较差异均无统计学意义（P＞0.05）；相关分析显示巨大儿脐血Be-tatrophin水平与新生儿出生体质量、身长、重量指数（PI）、脐血甘油三酯水平呈正相关（r=0.894、0.632、0.860、0.767，P＜0.001）；与脐血脂联素水平呈负相关（r=-0.398、P＜0.05）；与母血Betatrophin水平、孕前和分娩时体质量、孕前体质量指数（BMI）、孕期体质量指数增加量（ΔBMI）无相关性（P＞0.05）。结论：Be-tatrophin水平变化与巨大儿发生有关，脐血Betatrophin水平可反映胎儿的生长发育状况。

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	郑俊虎
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	胡晓娜
	王大化

关键词 ：促代谢因子, 巨大儿, 血脂, 重量指数, 脐血

Abstract：Objective: To investigate the 1evel of cord serum Betatrophin and its clinical significance in macrosomia. Methods: A cross-sectional study was conducted. Totally 30 macrosomias and 30 normal birth weight (NBW) infants were enrolled in the study. Puerpera and cord serum Betatrophin was determined.The correlation between cord serum Betatrophin and indexes of macrosomia development, lipid metabolic parameters and serum adiponectin were analyzed. Results: The serum Betatrophin in cord blood of macrosomia (1 088.338±67.749 ng/L) was significantly higher than that of in NBW (929.487±80.949 ng/L) (t=8.242, P<0.001). The blood fat showed no statistical difference between the two groups (P>0.05). According to Pearson correlation analysis, the serum Betatrophin level in cord blood had positive correlations with birth weight, lengh, ponderal index (PI) of neonates and triglyceride (TG) in cord blood (r=0.894, 0.632, 0.860, 0.767, P<0.001). There was negative correlation between serum betatrophin and adiponectin level in cord blood (r=-0.398, P<0.05). The serum Betatrophha level in cord blood was not correlated with Betatrophin in maternal blood, body mass before pregnancy and delivery, pre-pregnancy BMI or BMI increase during pregnancy (P>0.05). Conclusion: Alteration in serum Betatrophin is correlated with macrosomia. The Betatrophin level can reflect the status of feta1 development.

Key words： Betatrophin macrosomia blood fat ponderal index cord blood

基金资助:温州市科技计划项目（Y20170638）

作者简介: 郑俊虎（1975-），男，浙江瑞安人，主任医师。

链接本文:

https://xb.wmu.edu.cn/CN/10.3969/j.issn.2095-9400.2019.02.008 或 https://xb.wmu.edu.cn/CN/Y2019/V49/I2/113

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