ZHAO Yongzhong,YANG Chuang,WANG Weiqian, et al. Comparison of curative effect of duloxetine and paroxetine in treatment of generalized anxiety disorder with pain[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(4): 300-302.
Abstract：Objective: To evaluate the efficacy and safety of duloxetine and paroxetine in the treatment of generalized anxiety disorder with pain. Methods: Eighty seven patients were randomized into two groups. Forty four patients in duloxetine group were administered with duloxetine 60 mg/day and forty three patients in paroxetine group were treated with paroxetine 20 mg/day for 6 weeks. Efficacy were assessed with Visual Analogue Scale(VAS) for pain, Hamilton Anxiety Scale (HAMA) for anxiety, and Treatment Emergent Symptom Scale (TESS) for side effect. Results: As the duration of treatment, the VAS scores in the both groups were reduced significantly than that before treatment. At the end of 2, 4, 6 weeks after treatment, the VAS scores in duloxetine group were lower significantly than that in paroxetine group (P<0.05). The scores of HAMA and HAMA-somatic in duloxetine group were reduced significantly at the end of 2, 4 weeks after treatment than that in paloxetine group (P<0.05). The effective rate of treating the anxiety were 60.98% and 58.54% (P>0.05), and the recovery rate were 34.15% and 26.83% (P>0.05) in duloxetine group and paroxetine group, respectively. Conclusion: Duloxetine is an effective and safe antidepresent as paroxetine in treatment of generalized anxiety disorder with pain. Duloxetine is more effective against pain, and work faster than paroxetine in aspect of anxiety and pain.
