Correlative study on retinal vascular lesions on systemic lupus erythematosus and disease activity
1.Department of Rheumatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 2.Department of Ophthalmology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015
XIA Xiaoru1,XU Hong2,QIN Wei1, et al. Correlative study on retinal vascular lesions on systemic lupus erythematosus and disease activity[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(4): 268-271.
Abstract：Objective: To observe the early characteristics of systemic lupus erythematosus (SLE) patients with retinal vascular lesions and to investigate correlation between the degree of retinal vascular lesions and disease activity. Methods: The SLE patients were divided into 2 groups: experimental group (patient with retinal vasculopathy) and control group. All the patients were checked of vision, slit lamp, visualfield, OCT, fundus photograph, fundus fluorescence angiography (FFA) and then rated by the BenEzra scoring system, evaluating the relationship between ocular manifestation and lupus activity. Results: The early stage SLE patients showed different levels of retinal vascular lesion, including cotton wool spots, blood vessels expand circuity, retinal hemorrhage which may lead to proliferative retinopathy. Between two groups, patients with retinopathy have higher positive rate in Raynaud抯 phenomenon and ds-DNA (P<0.05). There was significant difference in the SLEDAI scoring (Z=-2.695, P=0.007). There was positive correlation bewteen the BenEzra score and SLEDAI scores (r= 0.836, P<0.001). Conclusion: Retinal vascular lesions can happen in early SLE, particularly with Raynaud抯 phenomenon; BenEzra plays important role in early judgment of desease activities and vasculitis on SLE.
