JIN Xiaosheng1,WU Lifeng1,QIAN Xiaoying1, et al. Clinical analysis of microscopic polyangiitis with pulmonary involvement in 20 cases[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2014, 44(3): 219-221.
Abstract：Objective: To analyze the clinical characters of pulmonary involvement in the patients with microscopic polyangiitis. Methods: Twenty cases of MPA with pulmonary involvement were analyzed retrospectively, including clinical manifestation, laboratory test results, chest high-resolution computed tomography, pulmonary function test and pathology. Results: The common symptoms were cough (85%), dyspnea (30%), expectoration (25%) and haemoptysis (20%). Erythrocyte sedimentation rate was elevated in 95% of MPA patients. C-reactive protein was elevated in 55%. The prevalence of positive MPO-ANCA antibodies in MPA patients was 90%, while PR3-ANCA was 5%. Chest HRCT manifestations consisted of ground-glass opacity, interstitial fibrosis, patchy infiltration, pleural effusion and bronchiectasis. Conclusions: The pulmonary is frequently involved in MPA. Pulmonary involvement is the initial manifestation. The chest radiographic and clinical manifestations are nonspecific. Serum ANCA and histopathologic biopsy can help to understand and diagnose MPA with pulmonary involvement early.
[6] Tzelepis GE, Kokosi M, Tzioufas A, et al. Prevalence and outcome of pulmonary fibrosis in microscopic polyangiitis [J]. Eur Respir J, 2010, 36(1): 116-121.
[7] Kim JJ, Park JK, Wang YP, et al. Diffuse alveolar hemor-rhage in a 39-year-old woman: unusual initial presentation of microscopic polyangiitis[J]. Korean J Thorac Cardiovas Surg, 2011, 44(6): 448-451.
