1．Department of Emergency,Ruian People's Hospital,Wenzhou，325200；2 Department ofPharmachology,Wenzhou Medical College，WenzhOU，325035；3．Department ofPharmacy,Yueqing Hospital Affiliated to Wenzhon Medical College，Wenzhou.325600
Abstract：Objective：To explore the antidepressant--like effects of trans··resveratrol on behavioral changes in ovariectomized mice and its possible mechanism．Methods：Sstablished were Perimenopausal model by ovariectomy and depression model by chronic unpredictable stress were established after three weeks’administration．Use forced swimming test(FST)and open field test to observe the behavioral changes in mice，the expression of brain—derived neurotrophic factor(BDNF)and B—cell lymphoma protein 2(Bci-2) protein in hippocampus were determined with immunohistochemistry，the levels of superoxide dismutase (SOD)，glutathione(GSH)and malondiaIdehyde(MDA)were detected．Results：Compared with OVX group，the immobility time in FST and MDA level were increased，activities in open field test were decreased,BDNF and Bcl一2 expression，the activity of SOD and GSH level were reduced in OVX+Stress group．Transresveratrol( 30 mg。kg一1’d。1 or 60 mg’kg一1‘d一1)could reverse these effects mentioned above．Conclusion：Trans—resveratrol can ameliorate depressive—like behaviors in ovariectomized mice，and the mechanism may be related to its neuroprotective and antioxidant effects．
