CD56、TPO、p63及CK19联合检测与甲状腺乳头状癌临床病理的相关性

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摘要目的：探讨CD56、TPO、p63及CK19联合检测与甲状腺乳头状癌（PTC）临床病理因素间的相互关系。方法：应用免疫组织化学SP法检测100例PTC中CD56、TPO、p63及CK19的表达，分析四种标志物与性别、年龄、病灶数目、病灶大小、病灶部位、被膜侵犯、淋巴结转移和组织学亚型等临床病理因素间的关系。结果：CD56、TPO、p63及CK19在100例PTC中的表达阳性率分别为11%、5%、17%、87%。四种标志物的表达与性别、年龄、病灶数目、病灶大小、病灶部位、有否淋巴结转移、组织学亚型无关，差异无统计学意义（P＞0.05），其中有被膜侵犯时CD56的表达阳性率显著低于无被膜侵犯时，差异有统计学意义（P＜0.05），其他三种抗体的表达与是否有被膜侵犯无关，差异无统计学意义（P＞0.05）。结论：CD56的表达与是否有被膜侵犯相关，有被膜侵犯时CD56的表达显著低于无被膜侵犯时，CD56低表达可预示PTC预后较差。

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	郦秀芳
	吕艳婷
	张海勇
	赵飞行
	胡孟钧

关键词 ：甲状腺乳头状癌, CD56, TPO, p63, CK19, 临床病理相关性

Abstract：

Objective: To explore the correlation between combined detection of CD56, TPO, p63 and CK19 and clinicopathologic parameter in papillary thyroid carcinoma. Methods: one hundred patients with PTC were detected by immunohistochemistry for the expression of the CD56, TPO, p63 and CK19, and the Chi-square test was utilized to statistical analyze the relation between the above markers and clinicopathologic parameter (gender, age, number, size, location, capsule invasion, lymph node metastasis, histologic subtype of lesion). Results: The expression positive rate of CD56, TPO, p63 and CK19 was 11%, 5%, 17%, 87% respectively in 100 cases of PTC. No correlation between four markers and the clinicopathologic parameters (gender, age, number, size, location, lymph node metastasis, histologic subtype of lesion), there was no statistically significant difference (P>0.05), but the expression of CD56 in cases with capsule invasion was significantly lower than without capsule invasion, the difference was statistically significant (P<0.05), there was no correlation between expression of the other three markers and capsule invasion, the difference was not statistically significant (P>0.05). Conclusion: There is correlation between the expression of CD56 and capsule invasion, the expression of CD56 in cases with capsule invasion was significantly lower than without capsule invasion, and the low expression can predict the poor prognosis in PTC.

Key words： papillary thyroid carcinoma CD56 TPO p63 CK19 clinicopathologic correlation

收稿日期: 2013-03-14

基金资助:绍兴市科技计划项目（2012D10004）

通讯作者: 胡孟钧，主任医师，Email：hu-menjun@163.com。

作者简介: 郦秀芳（1972-），女，浙江诸暨人，副主任医师。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2014/V44/I3/205

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