LIN Xiaoxiao,CAI Zhe,LIN Guangyong.. Micellar supramolecular hydrogel for delivery of hydrophobic anticancer drugs[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2018, 48(5): 355-360,365.
Abstract： Objective: To develop a micellar supra-molecular hydrogel composed of α-cyclodextrin (α-CD) and monomethoxy poly (ethylene glycol)-b-poly (e-caplactone) (MPEG5 000-PCL5 000) micelles and explore its feasibility for hydrophobic anticancer drug delivery. Methods: PTX as an object of hydrophobic antitumor drugs, drug-loaded supramolecular hydrogel was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of α-CD amount on the gelation time, mechanical strength and thixotropic property was studied by a rheometer. Results: Pay-load of paclitaxel (PTX) to supramolecular hydrogel was achieved by encapsulation of PTX into MPEG5 000-PCL5 000 micelles prior mixing with α-CD aqueous solution. In vitro release study showed that the release behavior of PTX from hydrogel could be modulated by changing the α-CD amount in the hydrogel. Furthermore, such supramolecular hydrogel could sustain the releasing of encapsulated PTX compared to free PTX, as indicated by the cytotoxicity assay in vitro. Conclusion: Successful preparation of supramolecular hydrogels loaded with antitumor drug PTX, which mainly through interactions with α-CD.
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