温州市食品环境雌激素污染状况及风险评估

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摘要目的：检测温州市食品中主要环境雌激素的含量，评估膳食暴露风险。方法：随机抽取该市常见的肉类、水产类、蔬菜类和粮谷类食品，采用高效液相色谱-质谱串联法检测壬基酚（NP）、雌二醇（E2）、炔雌醇（EE2）、双酚A（BPA）的含量，结合当地人群的膳食结构，计算人群膳食暴露量，评估健康风险。结果：全部样品中均检出环境雌激素，NP检出率（100%）为最高，EE2检出率（49.3%）为最低，近1/4食品同时检出四种环境雌激素，同时检出2种及以上环境雌激素的食品占96.6%；居民平均膳食暴露风险指数分别为：NP 1.09×10-2，E2 0.41，BPA 1.84×10-4；最大风险指数分别为：NP 2.88×10-2，E2 1.20，BPA 8.58×10-4。结论：被检食品中绝大部分能同时检出2种以上环境雌激素；温州市食品中NP和BPA的健康风险指数小于1，尚属于安全范围；E2的暴露量已有一定风险。

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	赵娜娜1
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	应晨江3
	叶晓蕾1

关键词 ：环境雌激素, 膳食暴露, 风险评估, 双酚A, 壬基酚

Abstract：Objective: To determine the levels of environmental estrogens (ESs) in foods in Wenzhou, and perform an assessment of the health risk of ESs. Methods: Randomly selected items from categories of meat, fish/shellfish products, vegetables and cereals of the city and the concentration of ESs, such as nonylphenol (NP), bisphenol A (BPA), ethinylestradiol (EE2) and estradiol (E2), were determined by LC-MS/MS. Daily dietary exposure and health risk index of each estrogen were calculated considering the dietary pattern of the local people. Results: ESs were detected in all samples, the highest detection rate was of NP (100%) while the lowest was of EE2 (49.3%). Four ESs were simultaneously detected in about 1/4 of the samples and two or more ESs were detected in 96.6% of foods. The average dietary exposure risk index of NP, EE2, and BPA were 1.09×10-2, 0.41, and 1.84×10-4 and the maximum dietary exposure risk index of NP, EE2, and BPA were 2.88×10-2, 1.20, and 8.85×10-4, respectively. Conclusion: Four ESs are detected in almost every food samples; The health risk index of NP, E2 and BPA is less than 1 in food samples in Wenzhou. But the exposure level of E2 may have risk to local residents.

Key words： environmental estrogens dietary exposure risk assessment bisphenol A nonylphenol

收稿日期: 2013-10-12

基金资助:国家自然科学基金资助项目（81030051）。

通讯作者: 叶晓蕾，教授，硕士生导师，Email：yexiaolei@ wzmc.edu.cn。

作者简介: 赵娜娜（1987-），女，山东滨州人，硕士生。

链接本文:

https://xb.wmu.edu.cn/CN/ 或 https://xb.wmu.edu.cn/CN/Y2014/V44/I3/173

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