Clinical significance of blood coagulation function and lupus anticoagulant detection in patients withankylosing spondylitis
PAN Xiaohao1, CHEN Liyang2, ZHOU Jian1
1.Department of Clinical Laboratory,Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou 325000, China; 2.Department of Clinical Laboratory, the Second People’s Hospital of Longwan District, Wenzhou 325000, China
PAN Xiaohao,CHEN Liyang,ZHOU Jian. Clinical significance of blood coagulation function and lupus anticoagulant detection in patients withankylosing spondylitis[J]. JOURNAL OF WEZHOU MEDICAL UNIVERSITY, 2024, 54(10): 839-842.
摘要目的：探讨凝血功能和狼疮抗凝物（LAC）检测在强直性脊柱炎（AS）患者中的临床意义。方法：选取2020年7月至2023年6月于温州市中西医结合医院就诊并确诊为AS的患者60例为实验组，同期60例体检健康人群为对照组，检测两组研究对象常规凝血功能［凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、凝血酶时间（TT）、D-二聚体（D-D）］和LAC指标水平，采用Mann-Whitney U 检验比较上述各项指标的差异，并绘制ROC曲线分析各指标的辅助诊断效能。结果：AS患者PT、APTT、FIB、D-D和LAC水平与健康对照组比较差异有统计学意义（P ＜0.05）。LAC、FIB、D-D辅助诊断AS的ROC曲线下面积分别为0.97、0.93、0.84；约登指数分别为0.90、0.78、0.58；灵敏度分别为96.70%、85.00%、71.70%。结论：AS患者存在血栓形成风险，凝血功能和LAC检测有一定的辅助诊断价值。
Abstract：Objective: To investigate the clinical significance of coagulation function and lupus anticoagulant(LAC) detection in patients with ankylosing spondylitis (AS). Methods: A total of 60 patients who were diagnosed with AS in Wenzhou Hospital of Integrated Chinese and Western Medicine from July 2020 to June 2023 were selected as the experimental group, and 60 healthy people during the same period were selected as the control group. The levels of routine coagulation function [prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer (D-D)] and LAC were detected in the two groups. Mann-Whitney U test was used to compare the differences in the above indicators, and ROC curve was drawn to analyze the auxiliary diagnostic efficiency of each indicator. Results: There was significant difference in the levels of PT, APTT, FIB, DD and LAC between AS patients and healthy control group (P<0.05). The area under ROC curve of LAC, FIB and D-D was 0.97, 0.93 and 0.84, respectively. The Youden index was 0.90, 0.78 and 0.58, respectively.The sensitivity was 96.70%, 85.00% and 71.70%, respectively. Conclusion: Patients with AS have the risk of thrombosis, and the detection of coagulation function and LAC is of certain value in the auxiliary diagnosis.
